Chronic kidney disease (CKD) means that the kidneys have become damaged over time, and they can’t filter blood as they should. This damage can cause wastes to build up in the body. CKD may get worse over many years and lead to kidney failure. Kidney failure is sometimes called end-stage kidney disease. Early on there are typically no symptoms. Later, leg swelling, feeling tired, vomiting, loss of appetite, or confusion may develop.