Changing the way we understand and treat kidney disease
The Kidney Precision Medicine Project is an ambitious, multi-year project funded by the NIDDK with the purpose of understanding and finding new ways to treat chronic kidney disease (CKD) and acute kidney injury (AKI).
We will accomplish this by obtaining kidney tissue from KPMP participants, analyzing it using state-of-the-art technologies, and developing next generation software tools to visualize and share the resulting data.
This will allow us to redefine kidney disease in molecular terms and identify novel targeted therapies.
Who We Are
The KPMP is made up of three distinct, but highly interactive, activity groups:
The recruitment sites are responsible for recruiting participants with AKI or CKD into the longitudinal study and performing the kidney biopsy.
Tissue Interrogation Sites
The tissue interrogation sites are responsible for developing and using innovative technologies to analyze the biopsy tissue.
The central hub is responsible for aggregating, analyzing, and visualizing the generated data and providing scientific, infrastructure, and administrative support for the KPMP consortium.
Building the Kidney Tissue Atlas with our Research
Our researchers will use the kidney biopsies to make multiple maps of the kidney (called the Kidney Tissue Atlas). These maps will show important cells, regions, and disease pathways that lead to chronic kidney disease (CKD) and acute kidney injury (AKI).
The research will help answer important questions for people with kidney disease, such as:
What type of kidney disease do I have?
What will happen to me?
What can I do about it?
Ultimately, KPMP research hopes to find new markers and treatment targets that make personalized, effective, and safe treatments possible for kidney diseases.
Want to collaborate with the KPMP?
News from the KPMP
Two of our KPMP investigators, Drs. Jonathan Himmelfarb and Laura Mariani, were featured in the March 2019 issue of Kidney News.
We recently had the honor of presenting at a session of ASN Kidney Week 2018 dedicated to the Kidney Precision Medicine Project (KPMP). The session began with Richard Knight, the current President of the American Association of Kidney Patients (AAKP) and co-chair of our community engagement working group (CEWG), discussing the impact of the CEWG on this project, with an emphasis on the specific influence from our patient representatives.
Recently, several members of the KPMP team met with ontology experts from across the country to establish a collaborative ontology discussion forum, with the goal of promoting productive KPMP ontology development to support our envisioned use cases.