Research Objectives

PARTICIPANT Recruitment
  • Biopsies
  • Biospecimens
  • Clinical phenotypes
Central Biorepository
  • Tissue & slides
  • Blood, urine, stool
Tissue Interrogation
  • Transcriptomics
  • Proteomics
  • Metabolomics
  • Imaging
Data Integration
  • Store
  • Standardize
  • Validate
Kidney Tissue Atlas
  • Analyze
  • Visualize
  • Share
PARTICIPANT Recruitment
  • Biopsies
  • Biospecimens
  • Clinical phenotypes
Central Biorepository
  • Tissue & slides
  • Blood, urine, stool
Tissue Interrogation
  • Transcriptomics
  • Proteomics
  • Metabolomics
  • Imaging
Data Integration
  • Store
  • Standardize
  • Validate
Kidney Tissue Atlas
  • Analyze
  • Visualize
  • Share

Within the research activity groups from tissue interrogation to data integration, the KPMP consortium manages the resources within the KPMP and externally in the broader scientific community to achieve the following research objectives:

  • Identify State/Transition Markers: Identify a set of cellular and molecular markers that classify cells as healthy, injured, activated, or undergoing recovery via adaptive or maladaptive repair.
  • Define Disease Subgroups: Use all available data, including the kidney tissue atlas, to define patient subgroups and allow for clinical stratification into distinct endophenotypes.
  • Identify Molecular Pathways: Use data to identify and understand healthy and disease pathways that are activated in a particular cell type in a particular subgroup of patients.
  • Discover Biomarkers: Discover a set of subgroup and pathway biomarkers (ideally plasma or urine protein/antibody pairs, but could be urinary exosomes, miRNA, epigenetic marks, etc.).
  • Create a Public Data Portal: Establish a publicly available data hub with clinical, imaging, cellular, and molecular data. Anonymized data will be available to the research community upon validation.
  • Build the Kidney Tissue Atlas: Create a set of maps used to classify and locate different cell types and interstitial components. The atlas will help define disease subgroups and identify cells, pathways, and targets for novel therapies.

It is expected that these resources will seed future partnerships, ancillary studies, investigator-initiated endeavors, and industry collaborations.

Tissue Interrogation Sites’ -omics Methods

We are developing and applying state-of-the-art methods to analyze and understand the molecular landscape of the biopsy tissue, employing both targeted and high-throughput, unbiased profiling.

Collaborate with the KPMP

The KPMP actively engages other academics, industry, and the broader scientific community as it works to deepen understanding of the kidneys.

The KPMP makes funding available from an Opportunity Pool to support new projects that meet KPMP scientific, infrastructure, and resource needs.

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