Objectives of the KPMP

The KPMP consortium will be responsible for establishing and managing critical resources for the KPMP, and the broader scientific community, to achieve the following objectives. It is expected that these resources will seed future partnerships, ancillary studies, investigator-initiated endeavors, and industry collaborations.

Public Resource

Establish a publicly available data hub with clinical, imaging, cellular, and molecular data. Anonymized data will be available to the research community upon validation.

Kidney Tissue Atlas

Create a set of maps used to classify and locate different cell types and interstitial components. The atlas will help define disease subgroups and identify cells, pathways, and targets for novel therapies.

State/Transition Markers

Identify a set of cellular and molecular markers that classify cells as healthy, injured, activated, or undergoing recovery via adaptive or maladaptive repair.

Disease Subgroups

Use all available data, including the kidney tissue atlas, to define patient subgroups and allow for clinical stratification into distinct endophenotypes.

Molecular Pathways

Use data to identify and understand healthy and disease pathways that are activated in a particular cell type in a particular subgroup of patients.

Biomarkers

Discover a set of subgroup and pathway biomarkers (ideally plasma or urine protein/antibody pairs, but could be urinary exosomes, miRNA, epigenetic marks, etc.).

COLLABORATING WITH THE KPMP

The KPMP is an open-source resource that will actively engage other academics, industry, and the broader scientific community as it works to deepen understanding of the kidneys.

Visit the Opportunity Pool page to learn more about one way to collaborate with the KPMP.